Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | GAA | P10253 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 8/20 | 0.40 |
| ▸ | MEN1 | O00255 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 2/20 | 0.37 |
| ▸ | BCHE | P06276 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13759333 | 0.86 | FES (0.38) | NPC1RAB9ASMN1; SMN2GAAKDM4E | |
| SCHEMBL13759330 | 0.80 | FES (0.39) | NPC1RAB9ASMN1; SMN2GAAKDM4E | |
| SCHEMBL424028 | 0.79 | PIKFYVE (0.54) | NPC1RAB9AGAAKDM4EMAPT | |
| SCHEMBL424029 | 0.79 | PIKFYVE (0.54) | NPC1RAB9AGAAKDM4EMAPT | |
| SCHEMBL428183 | 0.77 | MAPT (0.40) | NPC1RAB9ASMN1; SMN2GAAKDM4E | |
| SCHEMBL428182 | 0.77 | MAPT (0.40) | NPC1RAB9ASMN1; SMN2GAAKDM4E | |
| SCHEMBL13759267 | 0.77 | KDM4E (0.46) | KDM4EMAPTKMT2AALDH1A1SIGMAR1 | |
| SCHEMBL5801587 | 0.76 | MAPT (0.39) | NPC1RAB9ASMN1; SMN2GAAKDM4E | |
| SCHEMBL5801589 | 0.76 | MAPT (0.39) | NPC1RAB9ASMN1; SMN2GAAKDM4E | |
| SCHEMBL425850 | 0.76 | PIKFYVE (0.54) | NPC1RAB9ASMN1; SMN2GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009100406-A2 | TOPICAL FORMULATIONS FOR THE TREATMENT OF PSORIASIS | SYNTA PHARMACEUTICALS CORP. (US) | 2009-08-13 | — | — | WO | disclosed |