Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 10/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 9/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1363909 | 1.00 | PDE4B (0.44) | PDE4BCHRM3ROCK2CHRM2CHRM1 | |
| SCHEMBL1363440 | 0.96 | PDE4B (0.43) | PDE4BCHRM3ROCK2 | |
| SCHEMBL1365292 | 0.95 | PDE4B (0.41) | PDE4BCHRM3ROCK2CHRM2CHRM1 | |
| SCHEMBL1362849 | 0.95 | PDE4B (0.41) | PDE4BCHRM3ROCK2 | |
| SCHEMBL1363194 | 0.94 | CHRM3 (0.46) | PDE4BCHRM3CHRM2CHRM1 | |
| SCHEMBL13750901 | 0.93 | PDE4B (0.42) | PDE4BROCK2 | |
| SCHEMBL13761019 | 0.93 | PDE4B (0.42) | PDE4BROCK2 | |
| SCHEMBL1362398 | 0.93 | PDE4B (0.46) | PDE4BCHRM3 | |
| SCHEMBL1364272 | 0.92 | PDE4B (0.39) | PDE4BCHRM3CHRM2CHRM1 | |
| SCHEMBL3425104 | 0.92 | PDE4B (0.48) | PDE4BCHRM3CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009100168-A1 | DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS | GLAXO GROUP LIMITED (GB) | 2009-08-13 | — | — | WO | disclosed |