Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 13/20 | 0.50 |
| ▸ | PDE5A | O76074 | 4/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13761270 | 0.94 | PDE4B (0.48) | PDE4BPDE5A | |
| SCHEMBL8023899 | 0.93 | PDE4B (0.50) | PDE4BPDE5AMAPK1 | |
| SCHEMBL13761220 | 0.93 | PDE4B (0.51) | PDE4BPDE5AROCK2 | |
| SCHEMBL1364499 | 0.92 | PDE4B (0.50) | PDE4BPDE5AROCK2 | |
| SCHEMBL13761154 | 0.92 | PDE4B (0.48) | PDE4BPDE5A | |
| SCHEMBL13761218 | 0.92 | PDE4B (0.48) | PDE4BPDE5A | |
| SCHEMBL8002737 | 0.92 | PDE4B (0.48) | PDE4BPDE5A | |
| SCHEMBL13760949 | 0.91 | PDE4B (0.52) | PDE4BMAPK1 | |
| SCHEMBL13760956 | 0.91 | PDE4B (0.51) | PDE4BPDE5AMAPK1 | |
| SCHEMBL13760978 | 0.91 | PDE4B (0.51) | PDE4BMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009100168-A1 | DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS | GLAXO GROUP LIMITED (GB) | 2009-08-13 | — | — | WO | disclosed |