Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 12/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | WDR5 | P61964 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13761217 | 0.93 | PDE4B (0.53) | PDE4BNR3C1WDR5MAPK1PIK3CA | |
| SCHEMBL4191247 | 0.93 | PDE4B (0.45) | PDE4BNR3C1 | |
| SCHEMBL12062838 | 0.93 | PDE4B (0.49) | PDE4BNR3C1WDR5MAPK1 | |
| SCHEMBL1363664 | 0.93 | PDE4B (0.45) | PDE4BNR3C1 | |
| SCHEMBL1362407 | 0.92 | PDE4B (0.45) | PDE4BNR3C1MAPK1 | |
| SCHEMBL1362652 | 0.92 | PDE4B (0.44) | PDE4BNR3C1PIK3CA | |
| SCHEMBL1364865 | 0.92 | PDE4B (0.44) | PDE4BNR3C1MAPK1 | |
| SCHEMBL1362521 | 0.92 | PDE4B (0.44) | PDE4B | |
| SCHEMBL1364353 | 0.92 | PDE4B (0.44) | PDE4BNR3C1 | |
| SCHEMBL1362463 | 0.91 | PDE4B (0.43) | PDE4BNR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009100168-A1 | DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS | GLAXO GROUP LIMITED (GB) | 2009-08-13 | — | — | WO | disclosed |