Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 6/20 | 0.55 |
| ▸ | CDK1 | P06493 | 2/20 | 0.55 |
| ▸ | CDK2 | P24941 | 2/20 | 0.55 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.36 |
| ▸ | GAK | O14976 | 1/20 | 0.34 |
| ▸ | STK16 | O75716 | 1/20 | 0.34 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | MLKL | Q8NB16 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
| ▸ | ACLY | P53396 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2337910 | 0.93 | GSK3B (0.58) | GSK3BCDK1CDK2AAK1GAK | |
| SCHEMBL2334591 | 0.92 | GSK3B (0.60) | GSK3BCDK1CDK2AAK1GSK3A | |
| SCHEMBL2333809 | 0.81 | GSK3B (0.59) | GSK3BCDK1CDK2AAK1GAK | |
| SCHEMBL1378973 | 0.80 | GSK3B (0.64) | GSK3BCDK1CDK2GSK3AMAPK1 | |
| SCHEMBL1376133 | 0.80 | GSK3B (0.49) | GSK3BCDK1CDK2AAK1GSK3A | |
| SCHEMBL1377236 | 0.79 | GSK3B (0.57) | GSK3BCDK1CDK2AAK1GAK | |
| SCHEMBL1377458 | 0.77 | GSK3B (0.60) | GSK3BCDK1CDK2GSK3ACDC7 | |
| SCHEMBL4483090 | 0.76 | GSK3B (0.55) | GSK3BCDK1CDK2AAK1GAK | |
| SCHEMBL2334200 | 0.76 | GSK3B (0.53) | GSK3BCDK1CDK2ACLY | |
| SCHEMBL1374941 | 0.75 | GSK3B (0.57) | GSK3BCDK1CDK2ACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4764168-B2 | — | — | 2011-08-31 | — | — | JP | claimed |
| EP-1572200-A1 | AMINOINDAZOLE DERIVATIVES AND USE THEREOF AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-09-14 | — | — | EP | claimed |
| WO-2004062662-A1 | AMINOINDAZOLE DERIVATIVES AND USE THEREOF AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-07-29 | — | — | WO | claimed |