Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | CCNC | P24863 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1376214 | 1.00 | CCNT1 (0.31) | CCNT1CCNCCDK8CDK9KCNH2 | |
| SCHEMBL1376773 | 0.92 | KCNH2 (0.36) | CCNT1CCNCCDK8CDK9KCNH2 | |
| SCHEMBL1376775 | 0.92 | KCNH2 (0.36) | CCNT1CCNCCDK8CDK9KCNH2 | |
| SCHEMBL5202374 | 0.92 | KCNH2 (0.36) | CCNT1CCNCCDK8CDK9KCNH2 | |
| SCHEMBL5206576 | 0.88 | SCN9A (0.38) | CCNT1CCNCCDK8CDK9KCNH2 | |
| SCHEMBL1376021 | 0.84 | SCN9A (0.36) | CCNT1CCNCCDK8CDK9KCNH2 | |
| SCHEMBL1375573 | 0.84 | SCN9A (0.37) | CCNT1CCNCCDK8CDK9KCNH2 | |
| SCHEMBL1379084 | 0.83 | KCNH2 (0.36) | CCNT1CCNCCDK8CDK9KCNH2 | |
| SCHEMBL1375377 | 0.83 | KCNH2 (0.36) | CCNT1CCNCCDK8CDK9KCNH2 | |
| SCHEMBL1375373 | 0.83 | KCNH2 (0.36) | CCNT1CCNCCDK8CDK9KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4743463-B2 | — | — | 2011-08-10 | — | — | JP | claimed |
| JP-2002541245-A | — | — | 2002-12-03 | — | — | JP | claimed |
| EP-1165523-A1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | Krenitsky Pharmaceuticals, Inc. (US) | 2002-01-02 | — | — | EP | claimed |
| WO-2000061562-A1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC. (US) | 2000-10-19 | — | — | WO | claimed |
| EP-1165523-A1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | Krenitsky Pharmaceuticals, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000061562-A1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC. (US) | 2000-10-19 | — | — | WO | disclosed |