Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | KCNH3 | Q9ULD8 | 2/20 | 0.43 |
| ▸ | ICMT | O60725 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.39 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.39 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30888914 | 0.81 | HRH3 (0.55) | HRH3RXFP1HDAC3HDAC8HDAC6 | |
| SCHEMBL29198050 | 0.81 | HRH3 (0.55) | HRH3RXFP1HDAC3HDAC8HDAC6 | |
| SCHEMBL14065406 | 0.79 | HRH3 (0.54) | HRH3HDAC3HDAC8HDAC6ICMT | |
| SCHEMBL14065443 | 0.79 | HRH3 (0.54) | HRH3HDAC3HDAC8HDAC6ICMT | |
| SCHEMBL13762190 | 0.79 | MAPT (0.49) | HRH3KCNH3SMN1; SMN2MAPTHTT | |
| SCHEMBL9788107 | 0.78 | HRH3 (0.51) | HRH3RXFP1HDAC3HDAC8HDAC6 | |
| SCHEMBL23406283 | 0.78 | HDAC3 (0.52) | RXFP1HDAC3HDAC8HDAC6SMN1; SMN2 | |
| SCHEMBL14149932 | 0.78 | HRH3 (0.52) | HRH3HDAC3HDAC8HDAC6KCNH3 | |
| SCHEMBL7221434 | 0.77 | MEN1 (0.49) | RXFP1KCNH3ICMTSMN1; SMN2MAPT | |
| SCHEMBL6995577 | 0.77 | MAPT (0.71) | RXFP1KCNH3ICMTSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7557110-B2 | MAPKAP-K2; inflammatory disease, autoimmune disease, destructive bone disorder, cancer and/or tumour growth; 5-[(trans-4-aminocyclohexyl)amino]-3-fluoro-6-methyl(pyrazolo[1,5-a]pyri- midin-7-yl)}(4-iodophenyl)amine | TEIJIN PHARMA LIMITED (JP) | 2009-07-07 | — | — | US | disclosed |