SCHEMBL1376302

SCHEMBL1376302

Cn1ccc(NC(=O)c2ccccc2)n1

nearest known ligand 0.74

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 7/20 0.74
RAB9A P51151 6/20 0.74
LMNA P02545 4/20 0.56
SMN1; SMN2 Q16637 3/20 0.56
ALDH1A1 P00352 3/20 0.55
KDM4E B2RXH2 1/20 0.55
HTT P42858 1/20 0.55
MEN1 O00255 2/20 0.54
KMT2A Q03164 2/20 0.54
MAPT P10636 1/20 0.50
NOTUM Q6P988 1/20 0.50
HPGDS O60760 1/20 0.50
ACSS2 Q9NR19 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21590291 0.84 NPC1 (0.75) NPC1RAB9ALMNASMN1; SMN2ALDH1A1
SCHEMBL12579765 0.83 NPC1 (0.75) NPC1RAB9ALMNASMN1; SMN2ALDH1A1
SCHEMBL4015642 0.83 NPC1 (0.73) NPC1RAB9ALMNASMN1; SMN2ALDH1A1
SCHEMBL31752862 0.82 NPC1 (0.73) NPC1RAB9ALMNASMN1; SMN2ALDH1A1
SCHEMBL23884739 0.81 NPC1 (0.71) NPC1RAB9ALMNASMN1; SMN2ALDH1A1
SCHEMBL18131134 0.81 NPC1 (0.71) NPC1RAB9ALMNASMN1; SMN2ALDH1A1
SCHEMBL25442203 0.81 NPC1 (0.71) NPC1RAB9ALMNASMN1; SMN2ALDH1A1
Hydrochloric Acid SCHEMBL31753039 0.81 NPC1 (0.71) NPC1RAB9ALMNASMN1; SMN2ALDH1A1
SCHEMBL2667078 0.81 NPC1 (0.66) NPC1RAB9ALMNASMN1; SMN2ALDH1A1
SCHEMBL18421576 0.80 NPC1 (0.65) NPC1RAB9ALMNASMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015193229-A1 BET-PROTEIN INHIBITING 1,4-DIHYDROPYRIDO[3,4-B]PYRAZINONES WITH META-SUBSTITUTED AROMATIC AMINO- OR ETHER GROUPS BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2015-12-23 WO claimed
JP-4651714-B2 2011-03-16 JP claimed
EP-1915367-A1 HETEROARYLCARBAMOYLBENZENE DERIVATIVES FOR THE TREATMENT OF DIABETES AstraZeneca AB (SE) 2008-04-30 EP claimed
EP-1902052-A1 HETEROARYL BENZAMIDE DERIVATIVES FOR USE AS GLK ACTIVATORS IN THE TREATMENT OF DIABETES AstraZeneca AB (SE) 2008-03-26 EP claimed
EP-1856056-A1 PHENOXY BENZAMIDE COMPOUNDS WITH UTILITY IN THE TREATMENT OF TYPE 2 DIABETES AND OBESITY AstraZeneca AB (SE) 2007-11-21 EP claimed
EP-1802582-A1 BENZAMIDE DERIVATIVES THAT ACT UPON THE GLUCOKINASE ENZYME. AstraZeneca AB (SE) 2007-07-04 EP claimed
EP-1756076-A1 HETROARYL BENZAMIDE DERIVATIVES FOR USE AS GLK ACTIVATORS IN THE TREATMENT OF DIABETES AstraZeneca AB (SE) 2007-02-28 EP claimed
WO-2007017649-A1 HETEROARYLCARBAMOYLBENZENE DERIVATIVES FOR THE TREATMENT OF DIABETES ASTRAZENECA AB (SE) 2007-02-15 WO claimed
WO-2007007041-A1 HETEROARYL BENZAMIDE DERIVATIVES FOR USE AS GLK ACTIVATORS IN THE TREATMENT OF DIABETES ASTRAZENECA AB (SE) 2007-01-18 WO claimed
WO-2006040528-A1 PHENOXY BENZAMIDE COMPOUNDS WITH UTILITY IN THE TREATMENT OF TYPE 2 DIABETES AND OBESITY ASTRAZENECA AB (SE) 2006-04-20 WO claimed
WO-2006040529-A1 BENZAMIDE DERIVATIVES THAT ACT UPON THE GLUCOKINASE ENZYME ASTRAZENECA AB (SE) 2006-04-20 WO claimed
WO-2005121110-A1 HETROARYL BENZAMIDE DERIVATIVES FOR USE AS GLK ACTIVATORS IN THE TREATMENT OF DIABETES ASTRAZENECA AB (SE) 2005-12-22 WO claimed
WO-2019238067-A1 PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF BEIGENE, LTD. (KY) 2019-12-19 WO disclosed
EP-1915367-A1 HETEROARYLCARBAMOYLBENZENE DERIVATIVES FOR THE TREATMENT OF DIABETES AstraZeneca AB (SE) 2008-04-30 EP disclosed
EP-1902052-A1 HETEROARYL BENZAMIDE DERIVATIVES FOR USE AS GLK ACTIVATORS IN THE TREATMENT OF DIABETES AstraZeneca AB (SE) 2008-03-26 EP disclosed
EP-1802582-A1 BENZAMIDE DERIVATIVES THAT ACT UPON THE GLUCOKINASE ENZYME. AstraZeneca AB (SE) 2007-07-04 EP disclosed
EP-1718624-A1 BENZAMIDE DERIVATIVES AND THEIR USE AS GLUCOKINASE ACTIVATING AGENTS AstraZeneca AB (SE) 2006-11-08 EP disclosed
WO-2006040529-A1 BENZAMIDE DERIVATIVES THAT ACT UPON THE GLUCOKINASE ENZYME ASTRAZENECA AB (SE) 2006-04-20 WO disclosed
WO-2005121110-A1 HETROARYL BENZAMIDE DERIVATIVES FOR USE AS GLK ACTIVATORS IN THE TREATMENT OF DIABETES ASTRAZENECA AB (SE) 2005-12-22 WO disclosed
WO-2005080359-A1 BENZAMIDE DERIVATIVES AND THEIR USE AS GLUCOKINAE ACTIVATING AGENTS ASTRAZENECA AB (SE) 2005-09-01 WO disclosed