Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 6/20 | 0.47 |
| ▸ | GSK3B | P49841 | 6/20 | 0.47 |
| ▸ | AURKA | O14965 | 4/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | PPIA | P62937 | 1/20 | 0.41 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CASP1 | P29466 | 2/20 | 0.37 |
| ▸ | CASP7 | P55210 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8297919 | 0.81 | GSK3A (0.69) | GSK3AGSK3BAURKAEGFREIF2AK4 | |
| SCHEMBL13763823 | 0.81 | GSK3A (0.62) | GSK3AGSK3BAURKAEGFREIF2AK4 | |
| SCHEMBL5039537 | 0.77 | EGFR (0.48) | EGFRERBB2PPIASYK | |
| SCHEMBL13763827 | 0.75 | GSK3A (0.47) | GSK3AGSK3BAURKAEGFRUSP2 | |
| SCHEMBL13925826 | 0.75 | PPIA (0.41) | EGFRERBB2PPIAXDHSYK | |
| SCHEMBL13763921 | 0.74 | GSK3A (0.59) | GSK3AGSK3BAURKAEGFREIF2AK4 | |
| SCHEMBL13764047 | 0.74 | GSK3A (0.59) | GSK3AGSK3BAURKAEGFREIF2AK4 | |
| SCHEMBL13303718 | 0.74 | GSK3A (0.67) | GSK3AGSK3BAURKAEGFREIF2AK4 | |
| SCHEMBL13764010 | 0.74 | GSK3B (0.79) | GSK3AGSK3BAURKAEGFREIF2AK4 | |
| SCHEMBL13763871 | 0.74 | AURKA (0.78) | GSK3AGSK3BAURKAEGFREIF2AK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7560458-B2 | Triazolopyrimidine derivatives as glycogen synthase kinase 3 inhibitors | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-07-14 | — | — | US | disclosed |
| US-7560458-B2 | Triazolopyrimidine derivatives as glycogen synthase kinase 3 inhibitors | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-07-14 | — | — | US | disclosed |