Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | CLK2 | P49760 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL82416 | 0.91 | KDM4E (0.46) | KDM4EHPGDKCNH2ALDH1A1HSD17B10 | |
| SCHEMBL12361385 | 0.88 | KDM4E (0.36) | KDM4EHPGDKCNH2ALDH1A1HSD17B10 | |
| SCHEMBL12167364 | 0.87 | KDM4E (0.43) | KDM4EHPGDKCNH2ALDH1A1HSD17B10 | |
| SCHEMBL4748104 | 0.85 | CYP3A4 (0.40) | KDM4EHPGDKCNH2ALDH1A1HSD17B10 | |
| SCHEMBL12352918 | 0.85 | KCNH2 (0.35) | KDM4EHPGDKCNH2ALDH1A1HSD17B10 | |
| SCHEMBL12426651 | 0.82 | KCNH2 (0.39) | KDM4EHPGDKCNH2ALDH1A1HSD17B10 | |
| SCHEMBL10306125 | 0.78 | KCNH2 (0.42) | KDM4EHPGDKCNH2ALDH1A1HSD17B10 | |
| SCHEMBL762152 | 0.76 | CYP3A4 (0.41) | KDM4EHPGDKCNH2ALDH1A1HSD17B10 | |
| SCHEMBL10306128 | 0.76 | CYP3A4 (0.41) | KDM4EHPGDKCNH2ALDH1A1HSD17B10 | |
| SCHEMBL12427281 | 0.76 | CYP3A4 (0.41) | KDM4EHPGDKCNH2ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476429-B2 | Tri-, tetra-substituted-3-aminopyrrolidine derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-07-02 | — | — | US | disclosed |
| US-7563805-B2 | 7-[3-Amino-3,4-dimethylpyrrolidine-1-yl]-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-8-methyl-4-oxoquinoline-3-carboxylic acid: quinoline bactericide; broad spectrum, strong antibacterial activity for Grampositive/-negative including multiple resistant cocci; side effect reductcion; drug design | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2009-07-21 | — | — | US | disclosed |