Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 5/20 | 0.46 |
| ▸ | VNN1 | O95497 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 2/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1243189 | 0.85 | CYP19A1 (0.46) | KCNA5VNN1KCNH2CYP19A1MGLL | |
| SCHEMBL1242218 | 0.85 | KCNA5 (0.45) | KCNA5VNN1CYP19A1MGLLCTSS | |
| SCHEMBL1243799 | 0.83 | KCNA5 (0.55) | KCNA5VNN1KCNH2CYP19A1MGLL | |
| SCHEMBL1242304 | 0.83 | KCNA5 (0.47) | KCNA5VNN1KCNH2CYP19A1MGLL | |
| SCHEMBL9903713 | 0.82 | KCNA5 (0.46) | KCNA5VNN1KCNH2CYP19A1MGLL | |
| SCHEMBL4580519 | 0.81 | SMN1; SMN2 (0.47) | KCNA5VNN1SGMS2NAMPTCYP2C9 | |
| SCHEMBL1243076 | 0.81 | KCNA5 (0.46) | KCNA5VNN1KCNH2CYP19A1MGLL | |
| SCHEMBL9903840 | 0.80 | KCNA5 (0.44) | KCNA5VNN1KCNH2CYP19A1MGLL | |
| SCHEMBL9903845 | 0.80 | KCNA5 (0.44) | KCNA5VNN1KCNH2CYP19A1MGLL | |
| SCHEMBL1242307 | 0.80 | KCNA5 (0.48) | KCNA5VNN1KCNH2CYP19A1MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4719745-B2 | — | — | 2011-07-06 | — | — | JP | claimed |
| EP-1781635-A4 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO INC (US) | 2009-02-25 | — | — | EP | claimed |
| EP-1781635-A2 | POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2007-05-09 | — | — | EP | claimed |
| WO-2006015159-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2006-02-09 | — | — | WO | claimed |