Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 10/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.41 |
| ▸ | PTGIR | P43119 | 2/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1242980 | 0.75 | KCNA5 (0.65) | KCNA5KCNH2CYP3A4GAA | |
| SCHEMBL1242189 | 0.73 | KCNA5 (0.62) | KCNA5KCNH2CYP3A4 | |
| SCHEMBL1242188 | 0.73 | KCNA5 (0.62) | KCNA5KCNH2CYP3A4 | |
| SCHEMBL1242079 | 0.71 | KCNA5 (0.53) | KCNA5KCNH2EPHX2CYP3A4GAA | |
| SCHEMBL1243052 | 0.71 | KCNA5 (0.55) | KCNA5KCNH2EPHX2CYP3A4CYP19A1 | |
| SCHEMBL1242312 | 0.68 | KCNA5 (0.50) | KCNA5KCNH2EPHX2CYP3A4SLC6A3 | |
| SCHEMBL9902316 | 0.68 | KCNA5 (0.53) | KCNA5KCNH2EPHX2CYP3A4 | |
| SCHEMBL4195449 | 0.67 | KCNA5 (0.46) | KCNA5KCNH2EPHX2CYP3A4CYP19A1 | |
| SCHEMBL1242753 | 0.66 | KCNA5 (0.50) | KCNA5KCNH2CYP3A4 | |
| SCHEMBL4580891 | 0.65 | POLB (0.48) | KCNA5KCNH2EPHX2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4719745-B2 | — | — | 2011-07-06 | — | — | JP | claimed |
| EP-1781635-A4 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO INC (US) | 2009-02-25 | — | — | EP | claimed |
| EP-1781635-A2 | POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2007-05-09 | — | — | EP | claimed |
| WO-2006015159-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2006-02-09 | — | — | WO | claimed |