Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAK | O14976 | 8/20 | 0.58 |
| ▸ | RIPK2 | O43353 | 12/20 | 0.51 |
| ▸ | KDR | P35968 | 3/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.51 |
| ▸ | COQ8A | Q8NI60 | 5/20 | 0.49 |
| ▸ | NLK | Q9UBE8 | 5/20 | 0.49 |
| ▸ | RAF1 | P04049 | 1/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.43 |
| ▸ | STK16 | O75716 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13768384 | 0.89 | GAK (0.55) | GAKRIPK2KDRRETMAPK14 | |
| SCHEMBL13768244 | 0.87 | GAK (0.53) | GAKRIPK2KDRRETMAPK14 | |
| SCHEMBL13768249 | 0.86 | GAK (0.52) | GAKRIPK2KDRRETMAPK14 | |
| SCHEMBL13768388 | 0.84 | GAK (0.48) | GAKRIPK2KDRRETMAPK14 | |
| SCHEMBL2284234 | 0.83 | GAK (0.49) | GAKRIPK2KDRRETMAPK14 | |
| SCHEMBL2285466 | 0.83 | GAK (0.48) | GAKRIPK2KDRRETMAPK14 | |
| SCHEMBL13768081 | 0.83 | RAF1 (0.52) | GAKRIPK2KDRRETMAPK14 | |
| SCHEMBL13768651 | 0.82 | RIPK2 (0.57) | GAKRIPK2KDRRETMAPK14 | |
| SCHEMBL14035048 | 0.82 | RIPK2 (0.56) | GAKRIPK2KDRPKMYT1COQ8A | |
| SCHEMBL2286179 | 0.82 | GAK (0.48) | GAKRIPK2KDRRETMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080200-A1 | NOVEL SULPHOXIMIDE-SUBSTITUTED QUINOLINE AND QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-07-02 | — | — | WO | disclosed |
| EP-2072502-A1 | Sulfoximide substituted chinolin and chinazolin derivatives as kinase inhibitors | Bayer Schering Pharma Aktiengesellschaft (DE) | 2009-06-24 | — | — | EP | disclosed |