Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 19/20 | 0.72 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14072843 | 0.89 | EPHX2 (0.74) | EPHX2EPHX1GAARAB9A | |
| SCHEMBL5000909 | 0.87 | EPHX2 (0.74) | EPHX2EPHX1RAB9A | |
| SCHEMBL1425023 | 0.87 | EPHX2 (0.74) | EPHX2EPHX1RAB9A | |
| SCHEMBL4997641 | 0.87 | EPHX2 (0.73) | EPHX2EPHX1RAB9A | |
| SCHEMBL4010386 | 0.86 | EPHX2 (0.75) | EPHX2EPHX1RAB9A | |
| SCHEMBL13768769 | 0.85 | EPHX1 (0.62) | EPHX2EPHX1GAARAB9A | |
| SCHEMBL14984060 | 0.85 | EPHX2 (0.76) | EPHX2EPHX1GAARAB9A | |
| SCHEMBL4012140 | 0.85 | EPHX1 (0.69) | EPHX2EPHX1 | |
| SCHEMBL21750955 | 0.85 | EPHX1 (0.84) | EPHX2EPHX1GAARAB9A | |
| SCHEMBL4012735 | 0.84 | EPHX2 (0.70) | EPHX2EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009086426-A2 | SOLUBLE EPOXIDE HYDROLASE INHIBITORS FOR THE TREATMENT OF ENDOTHELIAL DYSFUNCTION | ARETE THERAPEUTICS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |
| WO-2008112022-A1 | 4 -PI PERIDINYLUREA COMPOUNDS AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS | ARETE THERAPEUTICS, INC. (US) | 2008-09-18 | — | — | WO | disclosed |