Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL718535 | 0.93 | TSHR (0.41) | TSHRMAPK1ALDH1A1PTGDRPTGDR2 | |
| SCHEMBL717059 | 0.87 | TSHR (0.38) | TSHRMAPK1ALDH1A1PTGDRPTGDR2 | |
| SCHEMBL718995 | 0.86 | PDE10A (0.50) | PTGDRPTGDR2PDE10ANR1I2CYP3A4 | |
| SCHEMBL719801 | 0.86 | PDE10A (0.44) | TSHRMAPK1ALDH1A1PTGDRPTGDR2 | |
| SCHEMBL1609158 | 0.81 | PDE10A (0.39) | TSHRMAPK1ALDH1A1PDE10ANR1I2 | |
| SCHEMBL718722 | 0.77 | ALOX5AP (0.36) | TSHRMAPK1ALDH1A1PDE10AKMT2A | |
| SCHEMBL721836 | 0.71 | PDE10A (0.53) | PDE10ANR1I2CYP3A4CYP2D6 | |
| SCHEMBL12713482 | 0.70 | SYK (0.36) | PDE10ANR1I2CYP3A4CYP2D6 | |
| SCHEMBL14440830 | 0.68 | PDE10A (0.58) | PDE10A | |
| SCHEMBL1609868 | 0.68 | PDE10A (0.35) | PDE10ANR1I2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009081112-A2 | CHEMICAL COMPOUNDS | SYNGENTA LIMITED (GB) | 2009-07-02 | — | — | WO | disclosed |