SCHEMBL13769265

SCHEMBL13769265

Cc1ccc2c(N3CC[C@@H](N)C3)nc(-c3ccccc3P)nc2c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.47
CHEK2 O96017 3/20 0.43
HRH4 Q9H3N8 2/20 0.41
IRAK1 P51617 1/20 0.41
IRAK4 Q9NWZ3 1/20 0.41
CYP1A2 P05177 3/20 0.39
CYP3A4 P08684 3/20 0.39
ALDH1A1 P00352 2/20 0.39
CYP2D6 P10635 2/20 0.39
HSD17B10 Q99714 1/20 0.39
TSHR P16473 3/20 0.39
CLK4 Q9HAZ1 2/20 0.39
USP2 O75604 2/20 0.39
CYP2C9 P11712 1/20 0.39
ALOX15 P16050 1/20 0.39
MAPK1 P28482 1/20 0.39
CYP2C19 P33261 1/20 0.39
CASP7 P55210 1/20 0.39
PRKCI P41743 1/20 0.39
KHK P50053 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13769235 0.94 HRH4 (0.45) MAPTCHEK2HRH4IRAK1IRAK4
SCHEMBL183511 0.88 CHEK2 (0.58) MAPTCHEK2HRH4CYP1A2CYP3A4
SCHEMBL184238 0.88 CHEK2 (0.58) MAPTCHEK2HRH4CYP1A2CYP3A4
SCHEMBL183512 0.88 CHEK2 (0.58) MAPTCHEK2HRH4CYP1A2CYP3A4
SCHEMBL13769465 0.86 CYP1A2 (0.53) MAPTCHEK2CYP1A2CYP3A4ALDH1A1
SCHEMBL14535451 0.85 MAPT (0.42) MAPTCHEK2HRH4IRAK1IRAK4
SCHEMBL2734806 0.83 ABCB1 (0.52) MAPTHRH4CYP1A2CYP3A4ALDH1A1
SCHEMBL14535453 0.82 MAPT (0.43) MAPTCHEK2HRH4CYP1A2CYP3A4
SCHEMBL1623958 0.82 SMAD3 (0.55) MAPTCHEK2HRH4ALDH1A1HSD17B10
SCHEMBL1623723 0.82 SMAD3 (0.55) MAPTCHEK2HRH4ALDH1A1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1784393-B1 QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS VERTEX PHARMA (US) 2009-07-01 EP disclosed