Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.34 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14440997 | 0.91 | MAPK14 (0.41) | MAPK14MAPK11LPAR2CARM1KDM4E | |
| SCHEMBL4017385 | 0.91 | MAPK14 (0.41) | MAPK14MAPK11LPAR2CARM1KDM4E | |
| SCHEMBL13769209 | 0.86 | MAPK14 (0.45) | MAPK14MAPK11TRPA1LPAR2 | |
| SCHEMBL4841418 | 0.81 | MAPK14 (0.41) | MAPK14MAPK11LPAR2CARM1ALDH1A1 | |
| SCHEMBL4837403 | 0.78 | MAPK14 (0.42) | MAPK14MAPK11LPAR2 | |
| SCHEMBL14441051 | 0.77 | MAPK14 (0.44) | MAPK14MAPK11TRPA1LPAR2CARM1 | |
| SCHEMBL4833047 | 0.77 | MAPK14 (0.41) | MAPK14MAPK11TRPA1LPAR2 | |
| SCHEMBL13764811 | 0.77 | MAPK14 (0.45) | MAPK14MAPK11TRPA1LPAR2 | |
| SCHEMBL4845132 | 0.77 | MAPK14 (0.41) | MAPK14MAPK11TRPA1LPAR2 | |
| SCHEMBL4842831 | 0.77 | MAPK14 (0.42) | MAPK14MAPK11TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7566708-B2 | Substituted pyrazolo{3,4-D}pyrimidines as p38 map kinase inhibitors | ROCHE PALO ALTO LLC (US) | 2009-07-28 | — | — | US | disclosed |