Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 7/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13770068 | 0.90 | CHEK1 (0.35) | CHEK1 | |
| SCHEMBL948816 | 0.89 | RPS6KA2 (0.38) | — | |
| SCHEMBL13770022 | 0.88 | CHEK1 (0.36) | CHEK1 | |
| SCHEMBL13769820 | 0.85 | KLKB1 (0.35) | CHEK1 | |
| SCHEMBL13770090 | 0.81 | CHEK1 (0.39) | CHEK1 | |
| SCHEMBL948893 | 0.81 | KLKB1 (0.40) | CHEK1 | |
| SCHEMBL13770152 | 0.81 | CHEK1 (0.42) | CHEK1 | |
| SCHEMBL13770437 | 0.81 | CHEK1 (0.38) | CHEK1 | |
| SCHEMBL13769818 | 0.81 | CHEK1 (0.38) | CHEK1 | |
| SCHEMBL13770020 | 0.80 | CHEK1 (0.45) | CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009093012-A1 | INDOLYL- PYRIDONE DERIVATIVES HAVING CHECKPOINT KINASE 1 INHIBITORY ACTIVITY | VERNALIS (R & D) LTD (GB) | 2009-07-30 | — | — | WO | disclosed |