Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 3/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 11/20 | 0.41 |
| ▸ | JAK2 | O60674 | 7/20 | 0.41 |
| ▸ | TYK2 | P29597 | 5/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 3/20 | 0.40 |
| ▸ | JAK1 | P23458 | 7/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3724674 | 0.88 | DPP4 (0.41) | DPP4DPP7DPP8DPP9JAK3 | |
| SCHEMBL3724681 | 0.88 | DPP4 (0.41) | DPP4DPP7DPP8DPP9JAK3 | |
| SCHEMBL3666892 | 0.75 | TYK2 (0.39) | JAK3JAK2TYK2AURKAAKT1 | |
| SCHEMBL3718042 | 0.70 | JAK1 (0.42) | JAK3JAK2TYK2AURKAJAK1 | |
| SCHEMBL3718044 | 0.70 | JAK1 (0.42) | JAK3JAK2TYK2AURKAJAK1 | |
| SCHEMBL13011188 | 0.67 | AKT1 (0.54) | AKT1 | |
| SCHEMBL15664399 | 0.66 | JAK3 (0.62) | JAK3AKT1JAK1 | |
| SCHEMBL2104963 | 0.66 | JAK3 (0.52) | JAK3JAK2TYK2JAK1 | |
| SCHEMBL20368699 | 0.65 | BTK (0.47) | JAK3JAK2TYK2AURKAAKT1 | |
| SCHEMBL12101575 | 0.65 | AKT1 (0.72) | AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009089352-A1 | PYRROLOPYRIDINES AS KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2009-07-16 | — | — | WO | disclosed |