Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | DHODH | Q02127 | 2/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | IL2 | P60568 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12848580 | 0.85 | NOTUM (0.44) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL12848875 | 0.84 | MAPT (0.48) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL13770697 | 0.83 | NOTUM (0.50) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL12848725 | 0.83 | KDM4E (0.46) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL13770532 | 0.83 | IL2 (0.55) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL12848723 | 0.82 | MAPT (0.45) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL12848954 | 0.81 | NOTUM (0.40) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL13770540 | 0.81 | KDM4E (0.53) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL12848755 | 0.79 | BTK (0.42) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL12848481 | 0.79 | MEN1 (0.42) | KDM4EALDH1A1MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009089305-A1 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2009-07-16 | — | — | WO | disclosed |