Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 5/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.47 |
| ▸ | CLK1 | P49759 | 3/20 | 0.47 |
| ▸ | CLK2 | P49760 | 2/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | CDK9 | P50750 | 2/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1467417 | 0.90 | MAPT (0.48) | DYRK1ACLK4DYRK1BCLK1CLK2 | |
| SCHEMBL1467601 | 0.88 | CLK1 (0.49) | DYRK1ACLK4DYRK1BCLK1CLK2 | |
| SCHEMBL1467639 | 0.82 | DYRK1A (0.47) | DYRK1ACLK4DYRK1BCLK1CLK2 | |
| SCHEMBL22887017 | 0.82 | MKNK1 (0.55) | DYRK1ACLK4DYRK1BCLK1CLK2 | |
| SCHEMBL1467431 | 0.75 | CCNT1 (0.48) | DYRK1ACLK4DYRK1BCLK1CLK2 | |
| SCHEMBL1469459 | 0.73 | DYRK1A (0.50) | DYRK1ACLK4DYRK1BCLK1MKNK1 | |
| SCHEMBL27793973 | 0.72 | IGF1R (0.60) | MAPTALOX15KDM4EALDH1A1 | |
| SCHEMBL1466687 | 0.71 | DYRK1A (0.50) | DYRK1ACLK4DYRK1BCLK1MKNK1 | |
| SCHEMBL4736883 | 0.70 | PIK3CG (0.62) | CDK2MAPTJAK2 | |
| SCHEMBL1468014 | 0.70 | DYRK1A (0.51) | DYRK1ACLK4DYRK1BCLK1MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701944-B1 | 2-(AMINO-SUBSTITUTED)-4-ARYL PYRAMIDINES AND RELATED COMPOUNDS USEFUL FOR TREATING INFLAMMATORY DISEASES | MILLENNIUM PHARM INC (US) | 2009-07-29 | — | — | EP | disclosed |