Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 4/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 7/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.38 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22410736 | 0.89 | CCNT1 (0.42) | CCNT1NTRK1CDK9KCNH2MAP4K4 | |
| SCHEMBL12343793 | 0.88 | CCNT1 (0.37) | CCNT1NTRK1CDK9KCNH2PRKCQ | |
| SCHEMBL1469149 | 0.84 | IKBKB (0.44) | CCNT1NTRK1CDK9KCNH2MAP4K4 | |
| SCHEMBL1468127 | 0.84 | PRKCQ (0.41) | CCNT1CDK9KCNH2MKNK1MKNK2 | |
| SCHEMBL1468011 | 0.83 | KCNH2 (0.36) | CCNT1CDK9KCNH2MKNK1MKNK2 | |
| SCHEMBL12343855 | 0.83 | KCNH2 (0.36) | CCNT1CDK9KCNH2MKNK1MKNK2 | |
| SCHEMBL13770762 | 0.83 | KCNH2 (0.36) | CCNT1CDK9KCNH2MKNK1MKNK2 | |
| SCHEMBL12344184 | 0.81 | SLC6A2 (0.43) | CCNT1CDK9KCNH2MKNK1MKNK2 | |
| SCHEMBL12343867 | 0.81 | SLC6A2 (0.43) | CCNT1CDK9KCNH2MKNK1MKNK2 | |
| SCHEMBL13770618 | 0.80 | OGA (0.38) | CCNT1CDK9MKNK1MKNK2HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701944-B1 | 2-(AMINO-SUBSTITUTED)-4-ARYL PYRAMIDINES AND RELATED COMPOUNDS USEFUL FOR TREATING INFLAMMATORY DISEASES | MILLENNIUM PHARM INC (US) | 2009-07-29 | — | — | EP | disclosed |