Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 5/20 | 0.41 |
| ▸ | FDFT1 | P37268 | 4/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13776019 | 0.91 | LPAR1 (0.45) | LPAR1FDFT1HSP90AA1HSP90AB1SMN1; SMN2 | |
| SCHEMBL13775957 | 0.87 | HSP90AA1 (0.38) | LPAR1HSP90AA1HSP90AB1SMN1; SMN2GAA | |
| SCHEMBL4124875 | 0.87 | LPAR1 (0.45) | LPAR1FDFT1SMN1; SMN2GAAKMT2A | |
| SCHEMBL4119464 | 0.87 | LPAR1 (0.51) | LPAR1FDFT1HSP90AA1HSP90AB1GAA | |
| SCHEMBL4113235 | 0.86 | LPAR1 (0.44) | LPAR1HSP90AA1HSP90AB1GAAKMT2A | |
| SCHEMBL13776413 | 0.86 | LPAR1 (0.46) | LPAR1HSP90AA1HSP90AB1SMN1; SMN2GAA | |
| SCHEMBL4119701 | 0.85 | LPAR1 (0.45) | LPAR1HSP90AA1HSP90AB1GAAKMT2A | |
| SCHEMBL4124330 | 0.84 | LPAR1 (0.40) | LPAR1FDFT1HSP90AA1HSP90AB1ALDH1A1 | |
| SCHEMBL4116446 | 0.84 | HSP90AA1 (0.42) | LPAR1FDFT1HSP90AA1HSP90AB1SMN1; SMN2 | |
| SCHEMBL13776183 | 0.84 | LPAR1 (0.45) | LPAR1HSP90AA1HSP90AB1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090181942-A1 | TRICYCLIC COMPOUNDS | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2009-07-16 | — | — | US | disclosed |
| US-20090181942-A1 | TRICYCLIC COMPOUNDS | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2009-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181942-A1 | TRICYCLIC COMPOUNDS | FDFT1, COASY, HMGCR | LPAR1 345/4885FDFT1 1/4885HSP90AA1 4018/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.