Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 12/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1242843 | 0.80 | KCNA5 (1.00) | KCNA5KCNH2CYP3A4KDM4EALDH1A1 | |
| SCHEMBL1242017 | 0.79 | KCNA5 (0.80) | KCNA5KCNH2CYP3A4KDM4EALDH1A1 | |
| SCHEMBL1243069 | 0.78 | KCNA5 (0.87) | KCNA5KCNH2CYP3A4KDM4EALDH1A1 | |
| SCHEMBL1377584 | 0.77 | KCNA5 (0.70) | KCNA5KCNH2CYP3A4ALDH1A1 | |
| SCHEMBL1242236 | 0.76 | KCNA5 (0.80) | KCNA5KCNH2CYP3A4 | |
| SCHEMBL1242316 | 0.75 | KCNA5 (1.00) | KCNA5KCNH2CYP3A4 | |
| SCHEMBL1242561 | 0.72 | KCNA5 (1.00) | KCNA5KCNH2CYP3A4KDM4ECYP1A2 | |
| SCHEMBL1243116 | 0.72 | KCNA5 (0.76) | KCNA5KCNH2CYP3A4KDM4ECYP1A2 | |
| SCHEMBL1243114 | 0.71 | KCNA5 (0.75) | KCNA5KCNH2CYP3A4 | |
| SCHEMBL1243317 | 0.70 | KCNA5 (0.68) | KCNA5KCNH2CYP3A4KDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4719745-B2 | — | — | 2011-07-06 | — | — | JP | claimed |
| EP-1781635-A4 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO INC (US) | 2009-02-25 | — | — | EP | claimed |
| EP-1781635-A2 | POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2007-05-09 | — | — | EP | claimed |
| WO-2006015159-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2006-02-09 | — | — | WO | claimed |