Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EP300 | Q09472 | 3/20 | 0.70 |
| ▸ | STAT3 | P40763 | 1/20 | 0.70 |
| ▸ | MCL1 | Q07820 | 14/20 | 0.59 |
| ▸ | HKDC1 | Q2TB90 | 7/20 | 0.59 |
| ▸ | BCL2 | P10415 | 4/20 | 0.57 |
| ▸ | BCL2L1 | Q07817 | 4/20 | 0.57 |
| ▸ | BCL2A1 | Q16548 | 4/20 | 0.57 |
| ▸ | BCL2L2 | Q92843 | 4/20 | 0.57 |
| ▸ | HK1 | P19367 | 3/20 | 0.57 |
| ▸ | KEAP1 | Q14145 | 6/20 | 0.56 |
| ▸ | NFE2L2 | Q16236 | 6/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | POLB | P06746 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | BLM | P54132 | 3/20 | 0.56 |
| ▸ | CFTR | P13569 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | GOPC | Q9HD26 | 3/20 | 0.56 |
| ▸ | TDP2 | O95551 | 3/20 | 0.56 |
| ▸ | NSD2 | O96028 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1428457 | 0.83 | EP300 (1.00) | EP300STAT3MCL1HKDC1BCL2 | |
| SCHEMBL2241344 | 0.74 | MCL1 (1.00) | EP300STAT3MCL1HKDC1BCL2 | |
| SCHEMBL2239398 | 0.73 | MCL1 (1.00) | EP300STAT3MCL1HKDC1BCL2 | |
| SCHEMBL17211721 | 0.73 | MCL1 (0.82) | EP300STAT3MCL1HKDC1BCL2 | |
| SCHEMBL14851297 | 0.72 | MCL1 (1.00) | EP300STAT3MCL1HKDC1BCL2 | |
| SCHEMBL2239169 | 0.72 | MCL1 (1.00) | EP300STAT3MCL1HKDC1BCL2 | |
| SCHEMBL14842934 | 0.72 | MCL1 (1.00) | EP300STAT3MCL1HKDC1BCL2 | |
| SCHEMBL14851295 | 0.72 | MCL1 (1.00) | EP300STAT3MCL1HKDC1BCL2 | |
| SCHEMBL29373585 | 0.72 | MCL1 (1.00) | EP300STAT3MCL1HKDC1BCL2 | |
| SCHEMBL12351845 | 0.72 | MCL1 (0.84) | EP300STAT3MCL1HKDC1BCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090175805-A1 | Neuraminidase Inhibitors and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2009-07-09 | — | — | US | disclosed |
| US-20090175805-A1 | Neuraminidase Inhibitors and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2009-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090175805-A1 | Neuraminidase Inhibitors and uses thereof | ENGASE, NEU1, NEU2 | EP300 2398/4885STAT3 3023/4885MCL1 4276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.