Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 13/20 | 0.59 |
| ▸ | AURKA | O14965 | 12/20 | 0.59 |
| ▸ | PLK4 | O00444 | 3/20 | 0.59 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.59 |
| ▸ | AURKC | Q9UQB9 | 2/20 | 0.59 |
| ▸ | ABL1 | P00519 | 2/20 | 0.59 |
| ▸ | BCR | P11274 | 2/20 | 0.59 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.59 |
| ▸ | STK25 | O00506 | 1/20 | 0.59 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.59 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.59 |
| ▸ | GAK | O14976 | 1/20 | 0.59 |
| ▸ | MUSK | O15146 | 1/20 | 0.59 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.59 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.59 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.59 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.59 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.59 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.59 |
| ▸ | JAK2 | O60674 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13785844 | 0.93 | AURKB (0.60) | AURKBAURKAPLK4RIPK1AURKC | |
| SCHEMBL13785499 | 0.93 | AURKB (0.61) | AURKBAURKAPLK4RIPK1AURKC | |
| SCHEMBL13785849 | 0.90 | AURKB (0.62) | AURKBAURKAPLK4RIPK1AURKC | |
| SCHEMBL4359686 | 0.90 | AURKB (0.63) | AURKBAURKAPLK4RIPK1AURKC | |
| SCHEMBL4364216 | 0.89 | AURKB (0.59) | AURKBAURKAPLK4RIPK1AURKC | |
| SCHEMBL13799832 | 0.88 | AURKB (0.65) | AURKBAURKAPLK4RIPK1AURKC | |
| SCHEMBL4359024 | 0.86 | AURKB (0.60) | AURKBAURKAPLK4RIPK1AURKC | |
| SCHEMBL12338745 | 0.86 | AURKA (0.67) | AURKBAURKAPLK4RIPK1AURKC | |
| Tozasertib SCHEMBL614528 | 0.86 | AURKB (0.78) | AURKBAURKAPLK4RIPK1AURKC | |
| SCHEMBL12338737 | 0.83 | AURKA (0.67) | AURKBAURKAPLK4RIPK1AURKC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009086012-A1 | AURORA INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |