Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 19/20 | 0.59 |
| ▸ | CSNK2A2 | P19784 | 19/20 | 0.59 |
| ▸ | CSNK2B | P67870 | 19/20 | 0.59 |
| ▸ | PIM3 | Q86V86 | 18/20 | 0.59 |
| ▸ | PIM2 | Q9P1W9 | 18/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1854539 | 0.85 | PIM1 (0.66) | PIM1CSNK2A2CSNK2BPIM3PIM2 | |
| SCHEMBL1853998 | 0.85 | PIM1 (0.59) | PIM1CSNK2A2CSNK2BPIM3PIM2 | |
| SCHEMBL1851778 | 0.81 | PIM1 (0.64) | PIM1CSNK2A2CSNK2BPIM3PIM2 | |
| SCHEMBL1853299 | 0.81 | CSNK2A2 (0.67) | PIM1CSNK2A2CSNK2BPIM3PIM2 | |
| SCHEMBL1852116 | 0.80 | PIM1 (0.63) | PIM1CSNK2A2CSNK2BPIM3PIM2 | |
| SCHEMBL1852417 | 0.80 | PIM1 (0.69) | PIM1CSNK2A2CSNK2BPIM3PIM2 | |
| SCHEMBL1853115 | 0.80 | PIM1 (0.62) | PIM1CSNK2A2CSNK2BPIM3PIM2 | |
| SCHEMBL1853094 | 0.80 | PIM1 (0.62) | PIM1CSNK2A2CSNK2BPIM3PIM2 | |
| SCHEMBL12660613 | 0.80 | CSNK2A2 (0.62) | PIM1CSNK2A2CSNK2BPIM3PIM2 | |
| SCHEMBL1853320 | 0.79 | PIM1 (0.61) | PIM1CSNK2A2CSNK2BPIM3PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009086264-A1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | EXELIXIS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |