Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYRO3 | Q06418 | 19/20 | 0.43 |
| ▸ | MERTK | Q12866 | 19/20 | 0.43 |
| ▸ | GAS6 | Q14393 | 19/20 | 0.43 |
| ▸ | FLT3 | P36888 | 17/20 | 0.43 |
| ▸ | AXL | P30530 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1378746 | 1.00 | TYRO3 (0.43) | TYRO3MERTKGAS6FLT3AXL | |
| SCHEMBL5209213 | 0.94 | TYRO3 (0.47) | TYRO3MERTKGAS6FLT3AXL | |
| SCHEMBL5209220 | 0.94 | TYRO3 (0.47) | TYRO3MERTKGAS6FLT3AXL | |
| SCHEMBL5207324 | 0.90 | HSP90AA1 (0.40) | TYRO3MERTKGAS6FLT3AXL | |
| SCHEMBL5207331 | 0.90 | HSP90AA1 (0.40) | TYRO3MERTKGAS6FLT3AXL | |
| SCHEMBL7157262 | 0.84 | MERTK (0.42) | TYRO3MERTKGAS6FLT3AXL | |
| SCHEMBL7157258 | 0.84 | MERTK (0.42) | TYRO3MERTKGAS6FLT3AXL | |
| Hydrochloric Acid SCHEMBL5203349 | 0.83 | MERTK (0.41) | TYRO3MERTKGAS6FLT3AXL | |
| Hydrochloric Acid SCHEMBL5203355 | 0.83 | MERTK (0.41) | TYRO3MERTKGAS6FLT3AXL | |
| SCHEMBL5203150 | 0.79 | BTK (0.40) | TYRO3MERTKGAS6FLT3AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4743463-B2 | — | — | 2011-08-10 | — | — | JP | claimed |
| JP-2002541245-A | — | — | 2002-12-03 | — | — | JP | claimed |
| EP-1165523-A1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | Krenitsky Pharmaceuticals, Inc. (US) | 2002-01-02 | — | — | EP | claimed |
| WO-2000061562-A1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC. (US) | 2000-10-19 | — | — | WO | claimed |
| EP-1165523-A1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | Krenitsky Pharmaceuticals, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000061562-A1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC. (US) | 2000-10-19 | — | — | WO | disclosed |