Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | PPM1D | O15297 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4450044 | 0.84 | PPM1D (0.34) | PPM1D | |
| SCHEMBL5549338 | 0.78 | — | — | |
| SCHEMBL15152157 | 0.77 | NR1H2 (0.40) | USP2SMN1; SMN2NR1H2CHRM2CHRM1 | |
| SCHEMBL13167071 | 0.77 | NR1H2 (0.46) | USP2SMN1; SMN2NR1H2RECQL | |
| SCHEMBL20722519 | 0.76 | USP2 (0.39) | USP2SMN1; SMN2NR1H2RECQL | |
| SCHEMBL30644078 | 0.73 | NR1H2 (0.38) | USP2SMN1; SMN2NR1H2CHRM2CHRM1 | |
| SCHEMBL15074463 | 0.73 | CHRM2 (0.45) | USP2SMN1; SMN2NR1H2CHRM2CHRM1 | |
| SCHEMBL13787489 | 0.73 | CHRM2 (0.45) | USP2SMN1; SMN2NR1H2CHRM2CHRM1 | |
| SCHEMBL4155674 | 0.72 | PIK3CD (0.46) | USP2SMN1; SMN2RECQL | |
| SCHEMBL4155678 | 0.72 | PIK3CD (0.46) | USP2SMN1; SMN2RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020198058-A1 | INHIBITORS OF RAF KINASES | KINNATE BIOPHARMA INC. (US) | 2020-10-01 | — | — | WO | disclosed |
| US-7557102-B2 | Pyrazolidine-1,2-dicarboxyldiphenylamide derivatives as coagulation factor Xa inhibitors for the treatment of thromboses | MERCK PATENT GMBH (DE) | 2009-07-07 | — | — | US | disclosed |