Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY1 | P47900 | 20/20 | 0.80 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.61 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.61 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.61 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4435196 | 0.89 | P2RY1 (1.00) | P2RY1OPRM1OPRD1OPRK1P2RX1 | |
| SCHEMBL4429041 | 0.88 | P2RY1 (1.00) | P2RY1OPRM1OPRD1OPRK1P2RX1 | |
| SCHEMBL4433739 | 0.86 | P2RY1 (1.00) | P2RY1OPRM1OPRD1OPRK1P2RX1 | |
| SCHEMBL4422614 | 0.84 | P2RY1 (1.00) | P2RY1OPRM1OPRD1OPRK1P2RX1 | |
| SCHEMBL13788705 | 0.81 | P2RY1 (0.78) | P2RY1OPRM1OPRD1OPRK1P2RX1 | |
| SCHEMBL13788725 | 0.81 | P2RY1 (0.79) | P2RY1OPRM1OPRD1OPRK1P2RX1 | |
| SCHEMBL4552153 | 0.79 | P2RY1 (0.85) | P2RY1OPRM1OPRD1OPRK1P2RX1 | |
| SCHEMBL4426301 | 0.77 | P2RY1 (1.00) | P2RY1OPRM1OPRD1OPRK1P2RX1 | |
| SCHEMBL15617093 | 0.75 | P2RY1 (1.00) | P2RY1OPRM1OPRD1OPRK1P2RX1 | |
| SCHEMBL4422600 | 0.75 | P2RY1 (1.00) | P2RY1OPRM1OPRD1OPRK1P2RX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1750704-B1 | UREA ANTAGONISTS OF P2Y1 RECEPTOR USEFUL IN THE TREATMENT OF THROMBOTIC CONDITIONS | BRISTOL MYERS SQUIBB CO (US) | 2009-07-22 | — | — | EP | disclosed |
| US-7550499-B2 | Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-06-23 | — | — | US | disclosed |
| US-7550499-B2 | Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-06-23 | — | — | US | disclosed |