Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 5/20 | 0.38 |
| ▸ | F7 | P08709 | 5/20 | 0.38 |
| ▸ | F3 | P13726 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13788909 | 0.87 | HTT (0.41) | TSHRSMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL4493753 | 0.76 | CASR (0.38) | TSHRSMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL27725299 | 0.65 | CYP2A6 (0.57) | SMN1; SMN2LMNAHTTALDH1A1TP53 | |
| SCHEMBL928111 | 0.63 | PDE4A (0.52) | TSHRSMN1; SMN2LMNAALDH1A1TP53 | |
| SCHEMBL22863463 | 0.63 | TLR7 (0.45) | TSHRSMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL6130736 | 0.62 | CYP2A6 (0.63) | SMN1; SMN2LMNAHTTALDH1A1TP53 | |
| SCHEMBL13749192 | 0.62 | CYP1A2 (0.50) | LMNAMETAP1 | |
| SCHEMBL13003905 | 0.62 | CYP1A2 (0.50) | LMNAMETAP1 | |
| SCHEMBL30719914 | 0.62 | KDM4E (0.65) | SMN1; SMN2LMNAHTTALDH1A1TP53 | |
| SCHEMBL16862718 | 0.62 | KDM4E (0.50) | TSHRSMN1; SMN2LMNAHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090186907-A1 | Pyrazinones As Cellular Proliferation Inhibitors | E.I. DUPONT DE NEMOURS AND COMPANY (US) | 2009-07-23 | — | — | US | disclosed |
| US-20080194585-A1 | Fungicidal Pyrazine Derivatives | SHARPE PAULA LOUISE | 2008-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194585-A1 | Fungicidal Pyrazine Derivatives | CBR3, CBR1, NR0B1 | TSHR 795/4885SMN1; SMN2 3995/4885LMNA 4221/4885 |
| US-20090186907-A1 | Pyrazinones As Cellular Proliferation Inhibitors | MKI67, NR0B1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | TSHR 150/4885SMN1; SMN2 3158/4885LMNA 2584/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.