Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.56 |
| ▸ | MAPK12 | P53778 | 8/20 | 0.56 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.56 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.56 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.56 |
| ▸ | CDK8 | P49336 | 2/20 | 0.50 |
| ▸ | CCNC | P24863 | 1/20 | 0.50 |
| ▸ | TNF | P01375 | 3/20 | 0.48 |
| ▸ | HCK | P08631 | 2/20 | 0.48 |
| ▸ | CIT | O14578 | 1/20 | 0.48 |
| ▸ | MUSK | O15146 | 1/20 | 0.48 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.48 |
| ▸ | STK10 | O94804 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | RAF1 | P04049 | 1/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13791926 | 0.88 | MAPK14 (0.58) | MAPK14MAPK12MAPK13MAPK11DDR2 | |
| SCHEMBL13791950 | 0.86 | MAPK14 (0.60) | MAPK14MAPK12MAPK13MAPK11CDK8 | |
| SCHEMBL13791934 | 0.85 | MAPK14 (0.55) | MAPK14MAPK12MAPK13MAPK11DDR2 | |
| SCHEMBL13791984 | 0.84 | MAPK14 (0.61) | MAPK14MAPK12MAPK13MAPK11DDR2 | |
| SCHEMBL3876835 | 0.84 | MAPK14 (0.53) | MAPK14MAPK12MAPK13MAPK11DDR2 | |
| Hydrochloric Acid SCHEMBL3874592 | 0.83 | MAPK14 (0.60) | MAPK14MAPK12MAPK13MAPK11DDR2 | |
| SCHEMBL13791902 | 0.83 | MAPK14 (0.64) | MAPK14MAPK12MAPK13MAPK11DDR2 | |
| SCHEMBL3884539 | 0.83 | MAPK14 (0.59) | MAPK14MAPK12MAPK13MAPK11DDR2 | |
| SCHEMBL3879350 | 0.81 | MAPK14 (0.61) | MAPK14MAPK12MAPK13MAPK11DDR2 | |
| SCHEMBL3878994 | 0.81 | MAPK14 (0.57) | MAPK14MAPK12MAPK13MAPK11DDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7541368-B2 | 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-{3-[1-(1-methyl-cyclopropanecarbonyl)-piperidin-4-ylmethyl]-phenyl}-urea; use in the treatment of disease states capable of being modulated by the inhibition of p38 kinase and tumor necrosis factor (TNF) | AVENTIS PHARMACEUTICALS INC. (US) | 2009-06-02 | — | — | US | disclosed |