Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 15/20 | 0.70 |
| ▸ | ADRA2A | P08913 | 13/20 | 0.70 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.58 |
| ▸ | HRH1 | P35367 | 1/20 | 0.58 |
| ▸ | HTR2B | P41595 | 1/20 | 0.58 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | PLCG2 | P16885 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | KLK7 | P49862 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13794780 | 0.90 | MCHR1 (0.58) | MCHR1ADRA2AHTR1AADRA1AHRH1 | |
| SCHEMBL13793351 | 0.89 | MCHR1 (0.65) | MCHR1ADRA2AHTR1AADRA1AHRH1 | |
| SCHEMBL13797507 | 0.83 | MCHR1 (0.74) | MCHR1ADRA2AHTR1AADRA1AHRH1 | |
| SCHEMBL13793503 | 0.83 | MCHR1 (0.86) | MCHR1ADRA2AHTR1AADRA1AHRH1 | |
| SCHEMBL13793310 | 0.82 | MCHR1 (1.00) | MCHR1ADRA2AHTR1AADRA1AHRH1 | |
| SCHEMBL13794161 | 0.82 | MCHR1 (0.73) | MCHR1ADRA2AHTR1AADRA1AHRH1 | |
| SCHEMBL13793469 | 0.81 | MCHR1 (0.61) | MCHR1ADRA2AHTR1AADRA1AHRH1 | |
| SCHEMBL13807717 | 0.79 | MCHR1 (0.64) | MCHR1ADRA2AHTR1AADRA1AHRH1 | |
| SCHEMBL13797190 | 0.79 | MCHR1 (0.56) | MCHR1ADRA2AHTR1AADRA1AHRH1 | |
| SCHEMBL4034406 | 0.79 | MCHR1 (0.68) | MCHR1ADRA2AHTR1AADRA1AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7544690-B2 | MCH receptor antagonists | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2009-06-09 | — | — | US | disclosed |
| US-7544690-B2 | MCH receptor antagonists | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2009-06-09 | — | — | US | disclosed |