Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.56 |
| ▸ | BCHE | P06276 | 2/20 | 0.56 |
| ▸ | ACHE | P22303 | 2/20 | 0.56 |
| ▸ | MCHR1 | Q99705 | 17/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 16/20 | 0.56 |
| ▸ | NPY5R | Q15761 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13795125 | 0.95 | MCHR1 (0.55) | APPBCHEACHEMCHR1ADRA2A | |
| SCHEMBL13793566 | 0.93 | MCHR1 (0.57) | APPBCHEACHEMCHR1ADRA2A | |
| SCHEMBL13794098 | 0.91 | MCHR1 (0.61) | APPBCHEACHEMCHR1ADRA2A | |
| SCHEMBL13795350 | 0.89 | MCHR1 (0.59) | MCHR1ADRA2ANPY5RHTR1AADRA1A | |
| SCHEMBL13795135 | 0.88 | APP (0.65) | APPBCHEACHEMCHR1ADRA2A | |
| SCHEMBL13793942 | 0.88 | MCHR1 (0.57) | MCHR1ADRA2ANPY5RHTR1AADRA1A | |
| SCHEMBL13795291 | 0.87 | MCHR1 (0.57) | MCHR1ADRA2ANPY5RMEN1KMT2A | |
| SCHEMBL5528497 | 0.87 | APP (0.59) | APPBCHEACHEMCHR1ADRA2A | |
| SCHEMBL5528502 | 0.87 | APP (0.59) | APPBCHEACHEMCHR1ADRA2A | |
| SCHEMBL13793969 | 0.87 | MCHR1 (0.62) | MCHR1ADRA2ANPY5RHTR1AADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7544690-B2 | MCH receptor antagonists | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2009-06-09 | — | — | US | disclosed |
| US-7544690-B2 | MCH receptor antagonists | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2009-06-09 | — | — | US | disclosed |