Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 17/20 | 0.68 |
| ▸ | ADRA2A | P08913 | 17/20 | 0.68 |
| ▸ | NPY5R | Q15761 | 6/20 | 0.68 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13795539 | 0.93 | MCHR1 (0.68) | MCHR1ADRA2ANPY5RHTR1AADRA1A | |
| SCHEMBL13797236 | 0.92 | MCHR1 (0.60) | MCHR1ADRA2ANPY5RHTR1AADRA1A | |
| SCHEMBL13795303 | 0.91 | MCHR1 (0.67) | MCHR1ADRA2ANPY5RHTR1AADRA1A | |
| SCHEMBL13793076 | 0.90 | MCHR1 (0.66) | MCHR1ADRA2ANPY5RHTR1AADRA1A | |
| SCHEMBL13796711 | 0.90 | MCHR1 (0.65) | MCHR1ADRA2ANPY5RHTR1AADRA1A | |
| SCHEMBL14606639 | 0.89 | MCHR1 (0.66) | MCHR1ADRA2ANPY5RHTR1AADRA1A | |
| SCHEMBL13795415 | 0.89 | MCHR1 (0.66) | MCHR1ADRA2ANPY5RHTR1AADRA1A | |
| SCHEMBL13793713 | 0.88 | MCHR1 (0.64) | MCHR1ADRA2ANPY5RHTR1AADRA1A | |
| SCHEMBL13792903 | 0.88 | MCHR1 (0.68) | MCHR1ADRA2ANPY5RHTR1AADRA1A | |
| SCHEMBL13795997 | 0.87 | MCHR1 (0.63) | MCHR1ADRA2ANPY5RHTR1AADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7544690-B2 | MCH receptor antagonists | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2009-06-09 | — | — | US | disclosed |
| US-7544690-B2 | MCH receptor antagonists | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2009-06-09 | — | — | US | disclosed |