Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TERT | O14746 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12453816 | 0.87 | SMN1; SMN2 (0.59) | SMN1; SMN2MAPTLIN28ATDP1HDAC1 | |
| SCHEMBL2474794 | 0.85 | CXCR4 (0.50) | SMN1; SMN2MAPTLIN28ATDP1HDAC1 | |
| SCHEMBL4094117 | 0.85 | CXCR4 (0.50) | SMN1; SMN2MAPTLIN28ATDP1HDAC1 | |
| SCHEMBL8211406 | 0.84 | SMN1; SMN2 (0.60) | SMN1; SMN2MAPTLIN28ATDP1HDAC1 | |
| SCHEMBL8208011 | 0.84 | SMN1; SMN2 (0.60) | SMN1; SMN2MAPTLIN28ATDP1HDAC1 | |
| SCHEMBL2818579 | 0.84 | SMN1; SMN2 (0.68) | SMN1; SMN2MAPTLIN28ATDP1HDAC1 | |
| SCHEMBL8209122 | 0.82 | TDP1 (0.66) | SMN1; SMN2MAPTLIN28ATDP1HDAC1 | |
| SCHEMBL8208243 | 0.82 | SMN1; SMN2 (0.66) | SMN1; SMN2MAPTLIN28ATDP1HDAC1 | |
| SCHEMBL29574935 | 0.82 | SMN1; SMN2 (0.71) | SMN1; SMN2MAPTLIN28ATDP1HDAC1 | |
| SCHEMBL4526885 | 0.82 | SMN1; SMN2 (0.66) | SMN1; SMN2MAPTLIN28ATDP1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009076434-A1 | INHIBITORS OF INTEGRIN VLA-4 | MOLECULAR INSIGHT PHARMACEUTICALS, INC. (US) | 2009-06-18 | — | — | WO | disclosed |