Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LYN | P07948 | 2/20 | 0.66 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.66 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.66 |
| ▸ | BRAF | P15056 | 7/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.40 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | SCARB1 | Q8WTV0 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13797940 | 0.89 | MAPK14 (0.66) | LYNMAPK9MAPK14BRAFABL1 | |
| SCHEMBL13797949 | 0.89 | MAPK14 (0.68) | LYNMAPK9MAPK14BRAFABL1 | |
| SCHEMBL13797944 | 0.87 | LYN (0.67) | LYNMAPK9MAPK14BRAFABL1 | |
| SCHEMBL13797952 | 0.85 | MAPK14 (0.72) | LYNMAPK9MAPK14BRAFGSK3A | |
| SCHEMBL13797943 | 0.85 | MAPK14 (0.72) | LYNMAPK9MAPK14BRAFSCARB1 | |
| SCHEMBL13797959 | 0.84 | LYN (0.68) | LYNMAPK9MAPK14BRAFGSK3A | |
| SCHEMBL3256057 | 0.84 | LYN (0.77) | LYNMAPK9MAPK14BRAF | |
| SCHEMBL13797938 | 0.84 | MAPK14 (0.73) | LYNMAPK9MAPK14BRAFSCARB1 | |
| SCHEMBL13797958 | 0.84 | LYN (0.72) | LYNMAPK9MAPK14BRAF | |
| SCHEMBL13797996 | 0.83 | MAPK14 (0.69) | LYNMAPK9MAPK14BRAFSCARB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7550461-B2 | Benzofuran and benzothiophene compounds useful in treating cytokine mediated diseases | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-06-23 | — | — | US | disclosed |
| US-7550461-B2 | Benzofuran and benzothiophene compounds useful in treating cytokine mediated diseases | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-06-23 | — | — | US | disclosed |