Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LYN | P07948 | 1/20 | 0.64 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.64 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.61 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SCARB1 | Q8WTV0 | 3/20 | 0.39 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | SYK | P43405 | 2/20 | 0.39 |
| ▸ | GSK3A | P49840 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13797999 | 0.92 | LYN (0.66) | LYNMAPK9MAPK14BRAFSCARB1 | |
| SCHEMBL13797949 | 0.89 | MAPK14 (0.68) | LYNMAPK9MAPK14BRAFSCARB1 | |
| SCHEMBL13797947 | 0.86 | MAPK14 (0.69) | LYNMAPK9MAPK14BRAFALDH1A1 | |
| SCHEMBL13797959 | 0.86 | LYN (0.68) | LYNMAPK9MAPK14BRAFGSK3A | |
| SCHEMBL13797943 | 0.85 | MAPK14 (0.72) | LYNMAPK9MAPK14BRAFSCARB1 | |
| SCHEMBL13797944 | 0.85 | LYN (0.67) | LYNMAPK9MAPK14BRAFSRC | |
| SCHEMBL13797953 | 0.85 | LYN (0.71) | LYNMAPK9MAPK14BRAF | |
| SCHEMBL13798008 | 0.84 | LYN (0.66) | LYNMAPK9MAPK14BRAFSCARB1 | |
| SCHEMBL3256057 | 0.84 | LYN (0.77) | LYNMAPK9MAPK14BRAFALDH1A1 | |
| SCHEMBL13797961 | 0.84 | LYN (0.66) | LYNMAPK9MAPK14BRAFSCARB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7550461-B2 | Benzofuran and benzothiophene compounds useful in treating cytokine mediated diseases | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-06-23 | — | — | US | disclosed |
| US-7550461-B2 | Benzofuran and benzothiophene compounds useful in treating cytokine mediated diseases | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-06-23 | — | — | US | disclosed |