Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LYN | P07948 | 1/20 | 0.69 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.69 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.62 |
| ▸ | BRAF | P15056 | 12/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13797956 | 0.92 | LYN (0.69) | LYNMAPK9MAPK14BRAFCYP1A2 | |
| SCHEMBL13797958 | 0.91 | LYN (0.72) | LYNMAPK9MAPK14BRAF | |
| SCHEMBL3252708 | 0.90 | LYN (0.67) | LYNMAPK9MAPK14BRAFCYP1A2 | |
| SCHEMBL3257628 | 0.90 | LYN (0.72) | LYNMAPK9MAPK14BRAF | |
| SCHEMBL13797953 | 0.89 | LYN (0.71) | LYNMAPK9MAPK14BRAF | |
| SCHEMBL13797952 | 0.88 | MAPK14 (0.72) | LYNMAPK9MAPK14BRAF | |
| SCHEMBL13798007 | 0.87 | LYN (0.71) | LYNMAPK9MAPK14BRAF | |
| SCHEMBL13797943 | 0.86 | MAPK14 (0.72) | LYNMAPK9MAPK14BRAF | |
| SCHEMBL13798003 | 0.86 | LYN (0.78) | LYNMAPK9MAPK14BRAF | |
| SCHEMBL3258067 | 0.85 | LYN (0.77) | LYNMAPK9MAPK14BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7550461-B2 | Benzofuran and benzothiophene compounds useful in treating cytokine mediated diseases | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-06-23 | — | — | US | disclosed |
| US-7550461-B2 | Benzofuran and benzothiophene compounds useful in treating cytokine mediated diseases | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-06-23 | — | — | US | disclosed |