Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.69 |
| ▸ | LYN | P07948 | 2/20 | 0.64 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.64 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 7/20 | 0.44 |
| ▸ | SRC | P12931 | 6/20 | 0.43 |
| ▸ | SYK | P43405 | 6/20 | 0.43 |
| ▸ | LCK | P06239 | 2/20 | 0.43 |
| ▸ | BRAF | P15056 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.42 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | SCARB1 | Q8WTV0 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13797952 | 0.91 | MAPK14 (0.72) | MAPK14LYNMAPK9GSK3ABRAF | |
| SCHEMBL13797943 | 0.89 | MAPK14 (0.72) | MAPK14LYNMAPK9BRAFSCARB1 | |
| SCHEMBL13797938 | 0.88 | MAPK14 (0.73) | MAPK14LYNMAPK9BRAFSCARB1 | |
| SCHEMBL13797996 | 0.87 | MAPK14 (0.69) | MAPK14LYNMAPK9BRAFSCARB1 | |
| SCHEMBL13797962 | 0.87 | MAPK14 (0.67) | MAPK14LYNMAPK9BRAFSCARB1 | |
| SCHEMBL13797947 | 0.86 | MAPK14 (0.69) | MAPK14LYNMAPK9BRAFSCARB1 | |
| SCHEMBL13359242 | 0.86 | MAPK14 (0.68) | MAPK14LYNMAPK9BRAFSCARB1 | |
| SCHEMBL13797949 | 0.86 | MAPK14 (0.68) | MAPK14LYNMAPK9GSK3ASRC | |
| SCHEMBL13798012 | 0.86 | LYN (0.60) | MAPK14LYNMAPK9GSK3ASRC | |
| SCHEMBL13797993 | 0.85 | MAPK14 (0.74) | MAPK14LYNMAPK9BRAFSCARB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7550461-B2 | Benzofuran and benzothiophene compounds useful in treating cytokine mediated diseases | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-06-23 | — | — | US | disclosed |
| US-7550461-B2 | Benzofuran and benzothiophene compounds useful in treating cytokine mediated diseases | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-06-23 | — | — | US | disclosed |