Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13798455 | 1.00 | CYP3A4 (0.39) | CYP3A4DDB1CRBN | |
| SCHEMBL7877471 | 0.93 | CYP3A4 (0.40) | CYP3A4DDB1CRBN | |
| SCHEMBL13798460 | 0.92 | CYP3A4 (0.32) | CYP3A4DDB1CRBN | |
| SCHEMBL13798459 | 0.92 | CYP3A4 (0.32) | CYP3A4DDB1CRBN | |
| SCHEMBL13798448 | 0.90 | DDB1 (0.34) | DDB1CRBN | |
| SCHEMBL13798452 | 0.90 | DDB1 (0.34) | DDB1CRBN | |
| SCHEMBL13798458 | 0.90 | DDB1 (0.34) | DDB1CRBN | |
| SCHEMBL13798457 | 0.89 | CYP3A4 (0.33) | CYP3A4 | |
| SCHEMBL12844643 | 0.89 | CYP3A4 (0.47) | CYP3A4DDB1CRBN | |
| SCHEMBL8378647 | 0.89 | CYP3A4 (0.47) | CYP3A4DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090155209-A1 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090155209-A1 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | EIF2AK2, HAVCR2, HCCS | CYP3A4 1594/4885DDB1 499/4885CRBN 1884/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.