Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TOP1 | P11387 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3288212 | 0.99 | KDM4E (0.41) | KDM4ELMNAHTTTOP1ALDH1A1 | |
| SCHEMBL4030026 | 0.89 | KDM4E (0.42) | KDM4ELMNAHTTTOP1ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL3291762 | 0.84 | KDM4E (0.37) | KDM4ELMNAHTTTOP1ALDH1A1 | |
| SCHEMBL5005805 | 0.84 | KDM4E (0.39) | KDM4ELMNAHTTTOP1ALDH1A1 | |
| SCHEMBL4179364 | 0.83 | TOP1 (0.42) | KDM4ELMNAHTTTOP1ALDH1A1 | |
| SCHEMBL4026856 | 0.83 | KDM4E (0.38) | KDM4ELMNAHTTTOP1ALDH1A1 | |
| SCHEMBL14530146 | 0.83 | KDM4E (0.38) | KDM4ELMNAHTTTOP1ALDH1A1 | |
| SCHEMBL5437272 | 0.82 | KDM4E (0.60) | KDM4ELMNAHTTTOP1ALDH1A1 | |
| SCHEMBL4961642 | 0.82 | KDM4E (0.38) | KDM4ELMNAHTTTOP1ALDH1A1 | |
| SCHEMBL14529767 | 0.82 | PPARA (0.38) | KDM4ELMNAHTTTOP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7547679-B2 | Ether linked macrolides useful for the treatment of microbial infections | GLAXOSMITHKLINE ISTRAZIVACKI CENTER ZAGREB D.O.O (HR) | 2009-06-16 | — | — | US | disclosed |