Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 18/20 | 0.49 |
| ▸ | PPARA | Q07869 | 16/20 | 0.49 |
| ▸ | PPARG | P37231 | 11/20 | 0.44 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1380117 | 0.91 | PPARD (0.61) | PPARDPPARAPPARG | |
| SCHEMBL2425200 | 0.90 | PPARD (0.41) | PPARDPPARAPPARGKDM5AKDM2B | |
| SCHEMBL1378075 | 0.89 | PPARA (0.45) | PPARDPPARAPPARGKDM5AKDM2B | |
| SCHEMBL1377558 | 0.87 | PPARD (0.47) | PPARDPPARAPPARG | |
| SCHEMBL1376252 | 0.83 | PPARD (0.55) | PPARDPPARAPPARG | |
| SCHEMBL1376739 | 0.83 | PPARD (0.54) | PPARDPPARAPPARG | |
| SCHEMBL5904770 | 0.82 | PPARD (0.62) | PPARDPPARAPPARG | |
| SCHEMBL5904729 | 0.81 | PPARA (0.62) | PPARDPPARAPPARG | |
| SCHEMBL2424756 | 0.81 | PPARD (0.50) | PPARDPPARA | |
| SCHEMBL2421669 | 0.80 | PPARD (0.39) | PPARDPPARAPPARGKDM5AKDM2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110237640-A1 | PYRAZOLE PHENYL DERIVATIVES | ACKERMANN JEAN | 2011-09-29 | — | — | US | claimed |
| JP-4733692-B2 | — | — | 2011-07-27 | — | — | JP | claimed |
| US-20100035953-A1 | Pyrazole Phenyl Derivatives | ACKERMANN JEAN | 2010-02-11 | — | — | US | claimed |
| EP-1742923-B1 | PYRAZOLE PHENYL DERIVATIVES AS PPAR ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2009-05-27 | — | — | EP | claimed |
| EP-1742923-A1 | PYRAZOLE PHENYL DERIVATIVES AS PPAR ACTIVATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-01-17 | — | — | EP | claimed |
| WO-2005105754-A1 | PYRAZOLE PHENYL DERIVATIVES AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-11-10 | — | — | WO | claimed |
| US-20050245589-A1 | Pyrazole phenyl derivatives | HOFFMANN-LA ROCHE INC. | 2005-11-03 | — | — | US | claimed |
| US-20110237640-A1 | PYRAZOLE PHENYL DERIVATIVES | ACKERMANN JEAN | 2011-09-29 | — | — | US | disclosed |
| US-20100035953-A1 | Pyrazole Phenyl Derivatives | ACKERMANN JEAN | 2010-02-11 | — | — | US | disclosed |
| EP-1742923-B1 | PYRAZOLE PHENYL DERIVATIVES AS PPAR ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2009-05-27 | — | — | EP | disclosed |
| EP-1742923-A1 | PYRAZOLE PHENYL DERIVATIVES AS PPAR ACTIVATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-01-17 | — | — | EP | disclosed |
| WO-2005105754-A1 | PYRAZOLE PHENYL DERIVATIVES AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-11-10 | — | — | WO | disclosed |
| US-20050245589-A1 | Pyrazole phenyl derivatives | HOFFMANN-LA ROCHE INC. | 2005-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035953-A1 | Pyrazole Phenyl Derivatives | PPARD, PPARG, PPARA | PPARD 1/4885PPARA 3/4885PPARG 2/4885 |
| US-20050245589-A1 | Pyrazole phenyl derivatives | PPARD, PPARG, PPARA | PPARD 1/4885PPARA 3/4885PPARG 2/4885 |
| US-20110237640-A1 | PYRAZOLE PHENYL DERIVATIVES | PPARD, PPARG, PPARA | PPARD 1/4885PPARA 3/4885PPARG 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.