Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.57 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.52 |
| ▸ | EGFR | P00533 | 2/20 | 0.51 |
| ▸ | IGF1R | P08069 | 2/20 | 0.51 |
| ▸ | AKT1 | P31749 | 1/20 | 0.50 |
| ▸ | CD38 | P28907 | 1/20 | 0.48 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | ACLY | P53396 | 2/20 | 0.47 |
| ▸ | APP | P05067 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ASPH | Q12797 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13802472 | 0.83 | FFAR1 (0.48) | MRGPRX4RPS6KB1CD38CISD1MEN1 | |
| SCHEMBL3808424 | 0.80 | GAA (0.62) | MRGPRX4CISD1MEN1GAAMAPT | |
| SCHEMBL4217682 | 0.80 | MAPT (0.77) | EGFRIGF1RMEN1GAAMAPT | |
| SCHEMBL2382952 | 0.78 | MRGPRX4 (0.53) | MRGPRX4RPS6KB1AKT1CD38CISD1 | |
| SCHEMBL15419642 | 0.76 | HSD17B10 (0.55) | MRGPRX4CISD1MEN1GAAMAPT | |
| SCHEMBL1403529 | 0.74 | APEX1 (0.50) | MRGPRX4RPS6KB1EGFRAKT1GAA | |
| SCHEMBL13802478 | 0.74 | KDM4E (0.50) | RPS6KB1MEN1GAAMAPTKMT2A | |
| SCHEMBL28647503 | 0.73 | GAA (0.58) | MRGPRX4RPS6KB1AKT1CD38CISD1 | |
| SCHEMBL22469681 | 0.73 | MRGPRX4 (1.00) | MRGPRX4MEN1KMT2A | |
| SCHEMBL31568452 | 0.73 | MRGPRX4 (1.00) | MRGPRX4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090155903-A1 | PHARMACEUTICAL COMPOSITION AND METHOD | MYRIAD GENETICS, INCORPORATED (US) | 2009-06-18 | — | — | US | disclosed |
| US-20090155903-A1 | PHARMACEUTICAL COMPOSITION AND METHOD | MYRIAD GENETICS, INCORPORATED (US) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090155903-A1 | PHARMACEUTICAL COMPOSITION AND METHOD | APP, PSEN2, PSEN1 | MRGPRX4 2781/4885RPS6KB1 4266/4885EGFR 3200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.