SCHEMBL13804644

SCHEMBL13804644

CC(=O)NC(Cc1cc(F)cc(F)c1)[C@H](S)CNC1COCc2ccccc21

nearest known ligand 0.65

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
BACE1 P56817 20/20 0.65
CTSD P07339 18/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4265272 1.00 BACE1 (0.65) BACE1CTSD
SCHEMBL4265275 1.00 BACE1 (0.65) BACE1CTSD
SCHEMBL3169455 0.92 BACE1 (0.77) BACE1CTSD
SCHEMBL3169462 0.92 BACE1 (0.77) BACE1CTSD
SCHEMBL8279303 0.92 BACE1 (0.77) BACE1CTSD
SCHEMBL4265278 0.89 BACE1 (0.63) BACE1CTSD
SCHEMBL4265280 0.89 BACE1 (0.63) BACE1CTSD
SCHEMBL3175486 0.85 BACE1 (0.65) BACE1CTSD
SCHEMBL3175477 0.85 BACE1 (0.65) BACE1CTSD
SCHEMBL13804642 0.83 BACE1 (0.68) BACE1CTSD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7544717-B2 2-amino- and 2-thio- substituted 1,3-diaminopropanes ELAN PHARMACEUTICALS, INC. (US) 2009-06-09 US disclosed