Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.64 |
| ▸ | ACHE | P22303 | 2/20 | 0.63 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.62 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.62 |
| ▸ | SLC6A12 | P48065 | 2/20 | 0.62 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.62 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 2/20 | 0.53 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.52 |
| ▸ | CCR3 | P51677 | 1/20 | 0.52 |
| ▸ | HTR6 | P50406 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL61297 | 0.93 | HDAC1 (0.63) | HDAC1HDAC6ACHEMCHR1SIGMAR1 | |
| SCHEMBL60695 | 0.92 | HDAC1 (0.58) | HDAC1HDAC6ACHEMCHR1SIGMAR1 | |
| SCHEMBL62174 | 0.91 | HDAC1 (0.64) | HDAC1HDAC6ACHEMCHR1SIGMAR1 | |
| SCHEMBL61826 | 0.91 | DRD4 (0.61) | HDAC1HDAC6ACHEMCHR1SIGMAR1 | |
| SCHEMBL61772 | 0.90 | HDAC1 (0.61) | HDAC1HDAC6ACHEMCHR1SIGMAR1 | |
| SCHEMBL61323 | 0.90 | AKR1B1 (0.57) | HDAC1HDAC6ACHESIGMAR1SLC6A12 | |
| SCHEMBL60899 | 0.90 | AKR1B1 (0.56) | HDAC1HDAC6ACHESLC6A12AKR1B1 | |
| SCHEMBL16927810 | 0.88 | HDAC1 (0.57) | HDAC1HDAC6ACHEMCHR1SIGMAR1 | |
| SCHEMBL61090 | 0.88 | HDAC1 (0.58) | HDAC1HDAC6ACHESLC6A12AKR1B1 | |
| SCHEMBL10168433 | 0.88 | HDAC1 (0.61) | HDAC1HDAC6ACHEMCHR1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009076631-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-06-18 | — | — | WO | disclosed |