Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 5/20 | 0.44 |
| ▸ | KIT | P10721 | 2/20 | 0.44 |
| ▸ | FLT3 | P36888 | 2/20 | 0.44 |
| ▸ | ABL1 | P00519 | 9/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.42 |
| ▸ | LCK | P06239 | 3/20 | 0.42 |
| ▸ | CSF1R | P07333 | 3/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.42 |
| ▸ | PRKACA | P17612 | 3/20 | 0.42 |
| ▸ | JAK2 | O60674 | 3/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.42 |
| ▸ | PLK4 | O00444 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 2/20 | 0.42 |
| ▸ | CDK1 | P06493 | 2/20 | 0.42 |
| ▸ | LYN | P07948 | 2/20 | 0.42 |
| ▸ | SRC | P12931 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL786493 | 0.74 | GAA (0.54) | PDPK1GAAMAP2K1KDRKIT | |
| SCHEMBL16680746 | 0.73 | PDPK1 (0.53) | PDPK1GAAMAP2K1KDRKIT | |
| SCHEMBL823576 | 0.72 | FGFR1 (0.48) | PDPK1GAAMAP2K1KDRKIT | |
| SCHEMBL16681387 | 0.70 | GAA (0.49) | PDPK1GAAMAP2K1KDRKIT | |
| SCHEMBL16681120 | 0.70 | PDPK1 (0.49) | PDPK1GAAMAP2K1KDRKIT | |
| SCHEMBL185907 | 0.70 | GAA (0.61) | PDPK1GAAMAP2K1KDRKIT | |
| SCHEMBL30248298 | 0.70 | GAA (0.61) | PDPK1GAAMAP2K1KDRKIT | |
| SCHEMBL30065304 | 0.69 | PDPK1 (0.66) | PDPK1GAAMAP2K1KDRKIT | |
| SCHEMBL628649 | 0.69 | PDPK1 (0.66) | PDPK1GAAMAP2K1KDRKIT | |
| SCHEMBL16681145 | 0.69 | GAA (0.47) | PDPK1GAAMAP2K1KDRKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765788-B1 | 3-AMINOINDAZOLE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SGK-ASSOCIATED DISEASES | MERCK PATENT GMBH (DE) | 2009-06-03 | — | — | EP | disclosed |