Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 7/20 | 0.59 |
| ▸ | NSD2 | O96028 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.32 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.31 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.31 |
| ▸ | EIF4EBP1 | Q13541 | 1/20 | 0.31 |
| ▸ | CCNK | O75909 | 1/20 | 0.31 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13811529 | 0.88 | HSP90AB1 (0.54) | HSP90AB1NSD2KCNH2HTR2CHTR2A | |
| SCHEMBL12161032 | 0.81 | HSP90AB1 (0.87) | HSP90AB1NSD2KCNH2HSP90AA1SRC | |
| SCHEMBL12161232 | 0.76 | HSP90AB1 (0.84) | HSP90AB1NSD2KCNH2HSP90AA1SRC | |
| SCHEMBL13811528 | 0.74 | HSP90AB1 (0.42) | HSP90AB1NSD2MCHR1HTR2CHTR2A | |
| SCHEMBL12161199 | 0.74 | HSP90AB1 (1.00) | HSP90AB1NSD2KCNH2HSP90AA1SRC | |
| SCHEMBL2567990 | 0.73 | HSP90AB1 (0.81) | HSP90AB1KCNH2HSP90AA1SRC | |
| SCHEMBL13811667 | 0.73 | HSP90AB1 (0.62) | HSP90AB1KCNH2HSP90AA1SRC | |
| SCHEMBL12160986 | 0.72 | HSP90AB1 (1.00) | HSP90AB1NSD2KCNH2HSP90AA1 | |
| SCHEMBL2565203 | 0.70 | HSP90AB1 (0.77) | HSP90AB1KCNH2HSP90AA1SRC | |
| SCHEMBL12161036 | 0.69 | HSP90AB1 (0.92) | HSP90AB1KCNH2HSP90AA1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090163490-A1 | Pyrrolopyrimidine Derivatives Used As HSP90 Inhibitors | VERNALIS (R&D) LTD. (GB) | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163490-A1 | Pyrrolopyrimidine Derivatives Used As HSP90 Inhibitors | HSP90AA1, HSP90AB1, RAF1 | HSP90AB1 2/4885NSD2 2144/4885KCNH2 2202/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.