Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 2/20 | 0.36 |
| ▸ | CDK2AP1 | O14519 | 2/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | AGER | Q15109 | 1/20 | 0.35 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.33 |
| ▸ | LYN | P07948 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | YES1 | P07947 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13811670 | 0.78 | HSP90AB1 (0.61) | HSP90AB1KCNH2 | |
| SCHEMBL12160916 | 0.75 | HSP90AB1 (0.64) | ADORA2AADORA1HSP90AB1KCNH2 | |
| SCHEMBL13811571 | 0.74 | HSP90AB1 (0.41) | ADORA2AADORA1HSP90AB1KDM4E | |
| SCHEMBL13798696 | 0.67 | HSP90AB1 (0.40) | ADORA2AADORA1HSP90AB1KCNH2KDM4E | |
| SCHEMBL13811668 | 0.66 | HSP90AB1 (0.59) | ADORA1HSP90AB1KCNH2 | |
| SCHEMBL9706141 | 0.64 | KDM4E (0.73) | KDM4ETSHRESR1 | |
| SCHEMBL3560182 | 0.62 | LRRK2 (0.69) | HSP90AB1KCNH2 | |
| SCHEMBL7863703 | 0.61 | KDM4E (0.67) | KDM4ETSHRESR1 | |
| SCHEMBL15636161 | 0.60 | CHRNA7 (0.51) | ADORA2AADORA1KDM4ETSHRESR1 | |
| SCHEMBL7136211 | 0.60 | KDR (0.54) | KDM4ETSHRCHEK1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090163490-A1 | Pyrrolopyrimidine Derivatives Used As HSP90 Inhibitors | VERNALIS (R&D) LTD. (GB) | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163490-A1 | Pyrrolopyrimidine Derivatives Used As HSP90 Inhibitors | HSP90AA1, HSP90AB1, RAF1 | ADORA2A 2485/4885ADORA1 2088/4885HSP90AB1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.