Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.61 |
| ▸ | RAB9A | P51151 | 5/20 | 0.61 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.55 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MAOA | P21397 | 3/20 | 0.51 |
| ▸ | MAOB | P27338 | 3/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | MMP1 | P03956 | 1/20 | 0.51 |
| ▸ | MMP2 | P08253 | 1/20 | 0.51 |
| ▸ | MMP9 | P14780 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL401830 | 0.82 | NPC1 (0.57) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL401829 | 0.82 | NPC1 (0.57) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL3794687 | 0.77 | NPC1 (1.00) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL29217646 | 0.76 | MAPT (0.59) | NPC1RAB9AMEN1KMT2AMAPT | |
| Iodide SCHEMBL30758613 | 0.75 | NPC1 (0.97) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL357999 | 0.74 | MEN1 (0.71) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL27841707 | 0.74 | NPC1 (0.71) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL29533340 | 0.73 | MEN1 (1.00) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL10344695 | 0.73 | MEN1 (1.00) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL4318168 | 0.73 | NPC1 (0.59) | NPC1RAB9AMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740591-B1 | 6,6-BICYCLIC RING SUBSTITUTED HETEROBICYCLIC PROTEIN KINASE INHIBITORS | OSI PHARM INC (US) | 2009-06-17 | — | — | EP | disclosed |